Molecular analysis of two mouse dilute locus deletion mutations: spontaneous dilute lethal20J and radiation-induced dilute prenatal lethal Aa2 alleles
MC Strobel, PK Seperack, NG Copeland… - … and Cellular Biology, 1990 - Am Soc Microbiol
The dilute (d) coat color locus of mouse chromosome 9 has been identified by more than
200 spontaneous and mutagen-induced recessive mutations. With the advent of molecular
probes for this locus, the molecular lesion associated with different dilute alleles can be
recognized and precisely defined. In this study, two dilute mutations, dilute-lethal20J (dl20J)
and dilute prenatal lethal Aa2, have been examined. Using a dilute locus genomic probe in
Southern blot analysis, we detected unique restriction fragments in dl20J and Aa2 DNA …
200 spontaneous and mutagen-induced recessive mutations. With the advent of molecular
probes for this locus, the molecular lesion associated with different dilute alleles can be
recognized and precisely defined. In this study, two dilute mutations, dilute-lethal20J (dl20J)
and dilute prenatal lethal Aa2, have been examined. Using a dilute locus genomic probe in
Southern blot analysis, we detected unique restriction fragments in dl20J and Aa2 DNA …
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